Possible Interaction: Gamma-Aminobutyric Acid and Haloperidol

“Pretreatment with haloperidol (0.5 and 1.0 mg/kg SC) also significantly antagonized the circling behavior induced by GABA and muscimol.”

“ Haloperidol , on the other hand, enhances the GABA level in the striatum in a dose-related manner.”

“A dose-dependent elevation of striatal gamma-aminobutyric acid (GABA) level was found under chronic treatment with haloperidol , a classical neuroleptic drug.”

“ Haloperidol treatment significantly increased striatal gamma-aminobutyric acid content and glutamic acid decarboxylase activity by 17% and 16% respectively.”

“ Haloperidol and imipramine were able to affect the evoked release of both taurine and GABA.”

“Both effects were prevented or reduced by haloperidol pretreatment (0.65 μmol ·kg−1 i.v.).6.It is concluded that GABA and glutamate released from the cerebral cortex and diffused into an epidural or cortical cup originate at least in part from the brain.”

“Neuroleptics including haloperidol and quetiapine enhanced the desensitization of the GABA (3 μM)‐current.”

“However, the selective elevation of basal dorsolateral striatum GABA release following chronic administration of haloperidol may contribute to the development of tolerance to catalepsy as well as providing an in vivo neurochemical marker of the long-term effects of haloperidol.”

“Furthermore, chronic haloperidol administration transiently increased, then decreased, GABA efflux in the substantia nigra.”

“Overall, clozapine has a preferential effect on mesocorticolimbic neurotransmission whereas haloperidol alters glutamate and GABA efflux within the extrapyramidal motor system.”

“These data are consistent with the idea that chronic HAL administration may be associated with a significant increase in the amount of GABA present in terminals surrounding pyramidal neurons of rat mPFC.”