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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Hallucinogens

Research Papers that Mention the Interaction

Since bursting is necessary for pyramidal cells to activate GABA interneurons, the suppression effect of PCP may further lead to a weakening of the connections from pyramidal cells and GABA interneurons, thereby contributing to PCP's psychotomimetic effects.
Journal of Pharmacology and Experimental Therapeutics  •  2003  |  View Paper
In animals treated with both para-chlorophenylalanine and para-chloroamphetamine, ketanserin or the hallucinogenic agonist (2,5-dimethoxy-4-iodophenyl)-2-aminoethane (2C-I) each appeared to decrease stimulated GABA release but this was not significant.
European journal of pharmacology  •  1996  |  View Paper