Possible Interaction: Gamma-Aminobutyric Acid and Glycine

“During treatment, an increase in the extracellular amino acids alanine, glycine , glutamate, aspartate, serine, threonine, and taurine was found demonstrating a significant influence on the intracellular pool of free amino acids induced by DAB.”

“Simultaneously, the contents of inhibitory amino acids GABA and Gly were increased significantly (P<0.01), while with a decrease tendency in excitatory amino acids Glu and Asp (with no statistical significance).”

“Inhibitory synaptic transmission mediated by glycine and GABA is thought to be essential in coordinated activation of muscles during locomotion, in particular, controlling temporal and spatial activation patterns of muscles of each joint of each limb on the left and right side of the body.”

“By applying glycine to native or recombinant glycine receptors, we show that response decay times are accelerated by addition of GABA , a weak partial agonist of glycine receptors.”

“Systematic variation in agonist exposure time revealed that fast synaptic time course may be achieved with submillisecond exposures to mixtures of glycine and GABA at physiological concentrations.”

“The releases of endogenous glutamate and GABA also were enhanced by GLY and the GLY-evoked release of endogenous glutamate, but not of endogenous GABA, was higher in SOD1-G93A(+) than in control animals.”

“In control mice glycine concentration‐dependently evoked [3H]D‐ASP and [3H]GABA release.”

“Many amino-acids have the property of either stimulating or inhibiting firing of neurones; thus glutamic acid excites many cells when it is applied locally, and y-aminobutyric acid (GABA) and glycine inhibit firing.”

“The substrate specificity of the high-affinity transporter was further studied and Gly-Sar, Leucine, gaboxadol, sarcosine, lysine, betaine, 5-hydroxythryptophan, proline and glycine reduced the GABA uptake to approximately 44-70% of the GABA uptake in the absence of inhibitor.”

“The elevated GABA concentration in the brain can enhance the encephalopathy, together with the elevated levels of glycine. (”

“In the head-injured patients, the concentrations of aspartate, glutamate, and glycine were 2− to 8-fold higher, and the concentration of GABA 56− to 317-fold higher than control values; the concentration of serine was unaffected.”