Possible Interaction: Gamma-Aminobutyric Acid and Glutamic Acid

“Except for Oleic acid and Stigmasterol, they could significantly elevate g-aminobutyric acid (GABA) and reduce glutamic acid (Glu) levels in the hypothalamus of mice.”

“In hormone treated animals incorporation into GABA glutamine and glutamic acid was less than that of the controls.”

“As a result, GABA and Glu were simultaneously presented meaningful contribution for classification of samples, and might be considered as potential differential compounds to the urine samples from cluster patients with different dementia stages.”

“Circulating MAO and GABA showed an increasing trend along with decreased glutamic acid levels after treatment, in the neurotic anxiety cases.”

“However, co-release of GABA and Glu influences postsynaptic ionotropic glutamatergic receptor subtypes, thus selectively influencing AMPAR-mediated currents.”

“Since glutamic acid and GABA are intimately involved in the central nervous system (CNS) functions, the alterations occurring in their levels during alloxan diabetes may be significant in bringing about a correlation between the diabetic state and the altered functional dynamics of the CNS.”

“In the absence of glucose, Glu (10-100 microM) decreased the intracellular GABA (2-fold), whereas the extracellular accumulation of GABA was increased by about 4-fold.”

“The excitatory effects of L-Glu and BIC and the inhibitory effects of GABA showed a dose-response relationship.”

“ GABA could reverse the effects of ACH and GLU.”

“ GABA , when applied iontophoretically, inhibited VM neuronal activity while bicuculline, L-glutamic acid and acetylcholine enhanced the firing rates of the same VM neurons.”