Possible Interaction: Gamma-Aminobutyric Acid and Glutamate

“The inhibition of synaptosomal and vesicular neurotransmitter uptake systems by extracts of P. parvum, P. patelliferum, and C. polylepis appeared to be due to similar mechanisms of action, since similar inhibition ratios between the uptake of L-glutamate and GABA were obtained in both synaptosomes and synaptic vesicles.”

“There are many causes for seizures, but one of them is an imbalance in the concentration of GABA relative to l-glutamate.”

“By day 23 cultures were resistant to the effects of both GABA and L-glutamate.”

“Although the microinjection of GABA into nearby sites elicited no direct effect, it greatly attenuated the hypothermic effects of glutamate subsequently administered to the same site.”

“Application of l-glutamate also increased GABA release.”

“ GABA released thus might serve to inhibit the release of l-glutamate from nerve terminals.”

“ L-glutamate (100 microM) decreased evoked GABA release from MBH of intact female rats in diestrus.”

“The depression of GABA depolarizations caused by the release of L-glutamate from afferent terminal and/or interneurons leads to a block of presynaptic inhibition (produced in the frog spinal cord by GABA) resulting in a positive feed-forward amplification of reflex transmission.”

“CPA chemical stimulation by L-glutamate produces an increase in arterial blood pressure (ABP) while its inhibition by GABA or glycine evokes marked hypotension.”

“Treatment of cultures with L-glutamate (500 microM) promoted a 5-7 fold increase in the rate of [3H]GABA efflux which was totally independent on the presence of calcium ions in the superfusing medium.”