Possible Interaction: Gamma-Aminobutyric Acid and Glucose

“Conclusions-Being a source of immediate energy, glucose can reduce the ATP-depletion-induced changes in GABA and oxygenation, which helps in encountering hypoxia.”

“Because glucose was found to inhibit GABA release, we investigated whether extracellular GABA can serve as a marker for glucose-induced mitochondrial activity and thus for the functional state of beta-cells.”

“An increase in level of D‐glucose (normal content, 11.1 mM) by 32, 60, and/or 100 mM (a range characteristic for hyperosmolar diabetic coma) increased the [3H]GABA release and inhibited the [3H]noradrenaline release evoked by both methods of stimulation.”

“Application of GABA depolarized β-cells and stimulated action potential firing in β-cells exposed to glucose.”

“ Glucose breakdown also contributes to the formation of the neurotransmitters acetylcholine, glutamate, aspartate, and GABA.”

“The effects of glucose and 2,4‐dinitrophenol on amino acid secretions from islets were tested and a suppressive effect of glucose on gamma‐aminobutyric acid release was observed, likely acting through adenosine triphosphate inactivation of glutamate decarboxylase.”

“ Glucose induced a decrease in levels of γ-aminobutyrate (GABA) and aspartate in rat islets and INS-1 832/13 cells, respectively.”

“Being a source of immediate energy, glucose can reduce the ATP-depletion-induced changes in GABA and oxygenation helps in overcoming reduction in oxygen supply.”

“Being a source of immediate energy, glucose can reduce the ATP-depletion-induced changes in GABA and oxygenation, which helps in encountering hypoxia.”

“ Glucose in the VMH dose-dependently stimulates GABA release, and this in turn dose-dependently suppresses the glucagon and epinephrine responses to hypoglycemia.”