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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Glucagon

Research Papers that Mention the Interaction

In 12 normal subjects, a single … dose of 5 or 10 g GABA , as compared to placebo, caused a significant (p less than 0.01) and dose-dependent (p less than 0.01) increase of plasma levels of immunoreactive insulin, C peptide and glucagon , without affecting plasma glucose concentration.
Metabolism: clinical and experimental  •  1982  |  View Paper
Glutamate stimulates and GABA inhibits glucagon release …
Diabetes  •  2016  |  View Paper
The inhibitory transmitter GABA hyperpolarizes alpha and delta cells via their GABA A receptors, and blocks the release of glucagon and somatostatin.
Molecular Cancer  •  2012  |  View Paper
Pancreatic beta cells express GAD and produce γ-aminobutyric acid GABA ), which inhibits alpha cell secretion of glucagon.
Diabetologia  •  2017  |  View Paper
GABA inhibits glucagon secretion by hyperpolarizing α-cells via type-A GABA receptors (GABAARs).
PloS one  •  2011  |  View Paper
We reported that the …-aminobutyric acid GABA ), in a crucial glucose-sensing region within the brain, the …), plays an important role in modulating the magnitude of the glucagon and epinephrine responses to hypoglycemia and investigated whether VMH GABAergic tone … in diabetes and therefore might contribute to defective counterregulatory responses.
Diabetes  •  2011  |  View Paper
Added to isolated mouse islets in the … 0.5 mmol/l glucose, gamma-aminobutyric acid (GABA) … glucagon release to a similar extent (46%) as 10 mmol/l glucose (55%), and the selective GABA(…) receptor (GABA(A)R) antagonist SR95531 substantially reversed the inhibition of glucagon release by high glucose.
Diabetes  •  2007  |  View Paper
In a similar way, ACh evoked a two-fold increase in glucagon … diabetic pancreas at 10(-4) M. In normal pancreatic tissue, GABA produced a slight but not significant increase in glucagon … 10(-4) M. In contrast to this it inhibited glucagon secretion from diabetic pancreatic … at all concentrations.
Tissue & cell  •  2000  |  View Paper
Particular attention was paid to glucagon release to test a recent hypothesis suggesting that GABA mediates the still unexplained glucose-induced inhibition of glucagon release.
Endocrinology  •  1991  |  View Paper
GABA also increased glucagon levels only under fasting conditions (1.3-fold, single dose, p < 0.05; 1.5-fold, repeated dose, p < 0.01).
Front. Pharmacol.  •  2015  |  View Paper