supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
supplement:
Ginkgolides
Research Papers that Mention the Interaction
“At 10 μM, 30 μM and 100 μM, the ginkgolides caused rightward shifts of GABA dose –response curves and reduced maximal GABA responses, characteristic of noncompetitive antagonists, while the potencies showed a clear dependence on GABA concentration, indicating apparent competitive antagonism.”
“Kinetic modelling … the ginkgolides exhibit saturation of … high concentrations of GABA , but this was only partially observed for ginkgolide B. It also suggests that there may be different binding sites … the closed and open states of the receptor, with a higher affinity for the receptor in the closed state.”
Mixed antagonistic effects of the ginkgolides at recombinant human ρ1 GABAC receptors“ Ginkgolides A , B, and C inhibited the direct action of gamma-aminobutyric acid (GABA) with K(i) values of 14.5+/-1.0, 12.7+/-1.7, and 16.3+/-2.4 microM respectively.”
“ Ginkgolides are antagonists of the inhibitory ligand-gated ion channels for the neurotransmitters glycine and gamma-aminobutyric acid (GABA).”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback