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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Gamma-Aminobutyric Acid
supplement:
Genistein
Research Papers that Mention the Interaction
“Genistein inhibited in a noncompetitive manner GABA-activated currents recorded from alpha1beta1gamma2S receptor constructs by reducing the maximum normalized response from 1.83 +/- 0.… +/- 3.9 microM. After mutating the two "functionally active" substrate tyrosine (Y) residues in gamma2S and expressing the mutant receptor alpha1beta1gamma2S(Y365F, Y367F), genistein … GABA ….”
Inhibition of GABAAReceptor Function by Tyrosine Kinase Inhibitors and Their Inactive Analogues“ Genistein significantly normalized altered expression of pro-inflammatory cytokines and membrane receptor of GABA and GluR. Our study suggests strong therapeutic potential of genistein in animal model of HE.”
Genistein Alleviates Neuroinflammation and Restores Cognitive Function in Rat Model of Hepatic Encephalopathy: Underlying Mechanisms“Enhanced levels of GABA and citrulline under the influence of genistein may be implicated in alterations of nitric oxide release and consequent neurological change (e.g. paralysis) in the parasite.”
“Extracellular application of the PTK inhibitors genistein (10−9 to 10−5 M) or lavendustin A (10−12 to 10−7 M) provoked a bell‐shaped potentiation of the whole‐cell current induced by GABA (3×10−6 M).”
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