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Possible Interaction: Gamma-Aminobutyric Acid and Gaba Antagonists

Research Papers that Mention the Interaction

The open probability (P(o)) of both K(Na) and K(Ca) channels was found to be increased by bath application of GABA , and this increase in Po was antagonized by coapplication of the GABAB antagonist CGP54626, suggesting that GABA(B)-like receptors mediate these actions.
Journal of neurophysiology  •  2013  |  View Paper
Furthermore, the GABAB receptor antagonist , SCH-50911, prevents GABA or synaptically induced depression.
Biological Cybernetics  •  2003  |  View Paper
GABA significantly increased melatonin levels in a dose‐dependent manner, its effect being reversed by a GABAA receptor antagonist , bicuculline, but not by saclofen, a GABAB antagonist.
Journal of neurochemistry  •  1999  |  View Paper
The gastrin and somatostatin responses to 10–4 M GABA were completely inhibited by the GABAA antagonist bicuculline (10–5 M) and the cholinergic blocker atropine (10–7 M), whereas the GABAB antagonist CGP 35348 (5 × 10–5 M) was ineffective.
Digestion  •  1998  |  View Paper
GABA‐A antagonist bicucilline (50 μM) was ineffective when infused locally …, but prolonged the increase in neuronal GABA release after nigral stimulation; the GABA levels were increased during two 3‐min samples to ∼165%, … role for GABA‐A receptors in regulating the release of GABA from nigrothalamic GABAergic neurons.
Synapse  •  1997  |  View Paper
The effect of GABA was concentration-dependent (1-1000 microM) and was blocked by a GABAA receptor antagonist , bicuculline (100 microM), or a GABAA chloride channel blocker, picrotoxin (100 microM), but not by a GABAB receptor antagonist, 2-hydroxysaclofen (100 microM).
Brain research. Developmental brain research  •  1997  |  View Paper
The effect was marginally significant at 1 microM and … at 20 microM. The action of 20 microM GABA was mimicked by the GABAB-receptor agonist, muscimol, but not … the GABAA-receptor agonist, baclofen, and completely blocked by the GABAA-receptor antagonists , bicuculline and picrotoxin, which lacked effect per se.
Biology of reproduction  •  1997  |  View Paper
Lightening of skin color with dopamine was inhibited by a D2 receptor antagonist (sulpiride), and the effect of GABA was blocked by both sulpiride and a GABAA receptor antagonist (bicuculline).
Endocrinology  •  1995  |  View Paper
The effect of GABA was counteracted by the GABAB receptor antagonist CGP 35348 [P-(3-aminopropyl)-P-diethoxymethylphosphinic acid] but was not influenced by the GABAA receptor antagonist SR 95531 [2-(3-carboxypropyl)-3-amino-6-paramethoxyphenylpyridazinium bromide].
Pharmacology  •  1993  |  View Paper
Phaclofen (10 microM, a GABAB receptor antagonist), but not bicuculline (10 microM, a GABAA receptor antagonist ), counteracted the inhibition of GABA overflow, although the inhibition of Asp and Glu overflow was not attenuated.
Brain Research  •  1993  |  View Paper
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