Possible Interaction: Gamma-Aminobutyric Acid and Gaba Agonists

“The capacitating effect of GABA was mimicked by a GABAA receptor agonist muscimol.”

“The results show that GABA as well as the GABA receptor agonists Muscimol ( GABAA agonist ) and Baclofen (GABAB agonist) caused a decrease in glutamate release in control rats paralleled by a similar reduction in synapsin I phosphorylation.”

“This potentiation is mediated by GABAB-like receptors as GABAB-receptor agonists and antagonists, respectively, mimicked and blocked the potentiating actions of GABA.”

“The addition of GABA and the GABA A‐type receptor agonist Muscimol inhibited stromal cell proliferation, promoted apoptosis, and arrested cells in S‐phase, followed by decreased expression of cyclin D3.”

“ GABA , at concentrations of 50μM and 100 μM, and the GABA agonist muscimol (50 μM), significantly inhibited the release.”

“The inhibitory effect of GABA (10−5 M) was mimicked by the GABAB receptor agonist baclofen (10−5 M).”

“ GABA inhibited anti-CD3 and antigen-specific T cell proliferation in vitro in a … was 1) mimicked by the GABA(A) receptor agonist muscimol (but not the GABA(B) receptor agonist baclofen), 2) blocked by GABA(A) receptor antagonists and … Cl- channel blocker (picrotoxin) and 3) enhanced by pentobarbital.”

“In identified photoreceptors from the marine mollusc Hermissenda, recent evidence has suggested that GABA , as well as the GABAB receptor agonist baclofen, might simultaneously modulate multiple conductances on the postsynaptic membrane.”

“Application of gamma-amino-butyric acid (GABA) strongly inhibited spike firing through a biphasic hyperpolarization and increase in membrane conductance, a response that reversed close to the presumed chloride equilibrium potential and was imitated by the GABAA receptor agonist muscimol.”

“The inhibitory effect of GABA on cAMP levels was mimicked by the GABAB receptor agonist baclofen (100 microM) and totally abolished by a 4-h pretreatment with pertussis toxin (0.1 microgram/ml).”