Possible Interaction: Gamma-Aminobutyric Acid and Gaba Agents

“These results show that nocturnal blood melatonin levels may be suppressed by the acute administration of a GABAergic agent , suggesting that GABA may be involved in the modulation of pineal activity in man.”

“Finally, we demonstrate that GABAergic synaptic currents are reduced upon specific blockage of the GABARAP– GABA A R complex formation.”

“Increase in the GABAergic activity may be achieved through direct agonism at the GABA A receptors, inhibition of enzymatic breakdown of GABA , or by inhibition of the GABA transport proteins (GATs).”

“Other agents modulate GABAergic "tone" by regulating the synthesis, transport or breakdown of GABA.”

“ GABA released from GABAergic interneurons upon activation of facilitatory 5-HT receptors, e.g., 5-HT2A or 5-HT3 receptors, mediates inhibition of the release of other neurotransmitters such as prefrontal neocortical dopamine or neocortical acetylcholine release, respectively.”

“One neuroprotective mechanism includes its ability to modulate gamma-aminobutyric acid (GABA) and enhance GABAergic neurotransmission.”

“Because GABA modulates the majority of inhibition that is ongoing in the brain, perturbations in GABAergic inhibition have the potential to result in seizures.”

“Benzodiazepines, phenobarbital, propofol, and other GABA agonists or analogues can effectively control symptoms of withdrawal from GABAergic agents.”

“Benzodiazepines, phenobarbital, propofol, and other GABA agonists or analogues can effectively control symptoms of withdrawal from GABAergic agents.”

“Transporters on GABAergic interneurons regulate ambient GABA concentration in a neuronal activity-dependent manner.”