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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Ezogabine
Research Papers that Mention the Interaction
“Additionally, ezogabine enhances γ-aminobutyric acid (GABA) activity and de novo GABA synthesis.”
Ezogabine: An Evaluation of Its Efficacy and Safety as Adjunctive Therapy for Partial-Onset Seizures in Adults“Isobolic analysis revealed that retigabine acts in synergy with GABA in displacing [3H]TBOB.”
“This synergy could be quantified by a molecular model in which GABA and retigabine both allosterically displace [3H]TBOB, and retigabine allosterically enhances the binding of GABA and vice versa with a factor of 4.”
Synergy between retigabine and GABA in modulating the convulsant site of the GABAA receptor complex.“In addition, retigabine potentiated inhibitory postsynaptic currents (IPSCs) mediated by activation of gamma-aminobutyric acid(A) (GABA(A)) receptors.”
“ Retigabine concentration dependently potentiated GABA induced currents in rat cortical neurones.”
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