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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Gamma-Aminobutyric Acid and Excitatory Amino Acid Antagonists

Research Papers that Mention the Interaction

It follows that if both decreasing excitatory activity with glutamatergic antagonists and increasing inhibitory activity with GABA agonists can reduce nicotineinduced increases in DA, a drug which possesses both mechanisms might also suppress nicotine-induced increases in neurotransmitter activity.
Synapse  •  2001  |  View Paper
The glutamatergic agonists NMDA, kainate, and AMPA also induced a significant [3H]GABA release.
Journal of neurochemistry  •  1995  |  View Paper
Depolarizing glutamate receptor agonists (glutamate, aspartate and kainic acid) applied in an in vitro perfusion system, stimulated massive release of [3H]GABA from frog and chick retina but not from rat retina.
Brain Research  •  1986  |  View Paper
Combinations of neuroprotective agents such as glutamate antagonists and calcium channel antagonists may be additive, and other combinations of neuroprotective agents, such as a glutamate antagonist with a gamma-aminobutyric acid (GABA) agonist, have even shown synergism in a rat stroke model.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association  •  1999  |  View Paper