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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“Paradoxically, DAMGO also presynaptically inhibited GABA release onto most LHb neurons.”
Mu Opioid Receptor Actions in the Lateral Habenula“Thus, DAMGO inhibition of the excitatory GABA synaptic activity would inhibit, rather than disinhibit (i.e. activate, as occurs in the adult), neurons of the descending inhibitory system.”
“The selective mu agonist DAMGO (300 nM) also attenuated the nicotine-mediated enhancement of GABA release, and the mu selective antagonist CTOP (1 microM) blocked the actions of DAMGO.”
“DPDPE, DAMGO and dynorphin-A (Dyn-A) also depressed the inward current produced by GABA ; the order of agonist potency was DPDPE > DAMGO > Dyn-A. Naloxone blocked the inhibitory effects of enkephalins and other opioid agonists on the GABA current.”
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