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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Colforsin
Research Papers that Mention the Interaction
“The potency of GABA to inhibit the formation of cAMP induced by a forskolin analog in a recombinant CHO cell line expressing GABA(B) receptors was increased by the modulators.”
Mechanisms of allosteric modulation at GABAB receptors by CGP7930 and GS39783: effects on affinities and efficacies of orthosteric ligands with distinct intrinsic properties“Electrophysiological experiments revealed that acute activation of adenylyl cyclase with forskolin increased the frequency of presynaptic GABA release.”
Contribution of Adenylyl Cyclase Modulation of Pre- and Postsynaptic GABA Neurotransmission to Morphine Antinociception and Tolerance“Agents that increase protein kinase A activity like forskolin and 8-bromo-cAMP also inhibited GABA uptake.”
“Intra-PAG perfusion with forskolin (100 microM), an activator of adenylate cyclase, increased dialysate glutamate and GABA levels.”
“Spontaneous GABA release was increased by the adenylate cyclase activator, forskolin , and the phorbol ester, phorbol 12,13-dibutyrate.”
“Application of 50 µM forskolin markedly accelerated the desensitization of whole-cell responses induced by 100 µM GABA or glycine without changing the peak amplitude of the response.”
“5 Forskolin , an activator of adenylyl cyclase (AC), significantly increased synaptic GABA release frequency.”
“Administration of forskolin (10 microM) prolonged the stimulatory phase and attenuated the inhibitory phase evoked by GABA and 3APS, indicating that cAMP modulates the response of melanotrophs to GABAA agonists.”
“Moreover, the threonine phosphorylation of DARPP‐32 produced by maximally effective doses of either forskolin (in striatum) or l‐3,4‐dihydroxyphenylalanine (in substantia nigra) was increased further by GABA.”
“Extracellular application of either forskolin or 8-bromo-cyclic AMP potentiated IGABA , as did the introduction of cyclic AMP directly into the intracellular compartment through the recording pipet.”
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