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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
drug:
Cefepime
Research Papers that Mention the Interaction
“Regarding the pathogenesis, as the authors …, the commonly accepted hypothesis is that cefepime acts as a … antagonist of gamma-amino butyric acid (GABA) and subsequently inhibits the inhibitory response, which leads to the over-excitation of electrical activity of neurons and the occurrence of neurological symptoms, including seizure [2].”
Cefepime-Induced Encephalopathy: A Possible Additional Mechanism of Neurotoxicity“The cefepime level was significantly elevated at 160 µg/mL. Although not completely understood, cefepime is felt to antagonize gamma-aminobutyric acid A (GABA-A) receptors and possibly inhibit GABA release.”
Cefepime-Induced Encephalopathy“ Cefepime can cross the blood-brain barrier and can be neurotoxic by competitive albeit weak antagonism of the gamma-aminobutyric acid complex.”
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