Possible Interaction: Gamma-Aminobutyric Acid and Calcium Supplement

“Application of the neurotransmitters GABA , glutamate and acetylcholine induced depolarizing calcium signal changes in neuronal cells providing evidence for the excitatory effects of these ligand-gated ion channels during maturation in vitro.”

“The transient increase in intracellular calcium following the depolarizing action of GABA leads to inhibition of DNA synthesis and cell proliferation.”

“Through the depolarization of immature cerebellar neurons, GABA increases intracellular calcium and the phosphorylation of mitogen-activated protein kinase (MAPK) and Calmodulin-Dependent Protein Kinase II CaMKII.”

“These results indicate that GABA may be involved in the modulation of the AR and the fertilization process in capacitated human spermatozoa through a calcium mediated mechanism, thus opening up possibilities for studies of signal transductions through activation of the GABAA receptor present on the sperm surface.”

“Several neurotransmitters (noradrenaline, GABA , 5 HT and dopamine) all inhibit Ca 2÷ currents recorded from chick sensory neurones, this shows convergence of receptor mechanisms onto a single effector, the Ca 2+ channel.”

“In [35S]-GTPgammaS binding assays, Ca2+ ion (1 mM) enhanced the potency of the agonists GABA and 3-aminopropylphosphinic acid (3-APA) and that of the antagonist CGP55845, but not that of the GABA(B) receptor agonist (-)-baclofen.”

“These findings suggest that dopamine-induced calcium signal may stimulate release of neuromodulators such as GABA and adrenaline and thus suppress spontaneous calcium oscillations in neurons.”

“ GABA repolarized the membrane and shut off such calcium rises.”

“On activation, both GABAR types triggered synergistically intracellular calcium rise.”

“We found that GABA induces membrane depolarization and Ca2+ elevation in NG2 cells, a process requiring activation of GABAA receptors, Na+ channels, and Na+/Ca2+ exchangers (NCXs), but not Ca2+ channels.”