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Possible Interaction: Gamma-Aminobutyric Acid and Brotizolam

Research Papers that Mention the Interaction

2) brotizolam inhibition of GABA (300 microM)-stimulated chloride influx involves an additional mechanism, and 3) the sedative-hypnotic action of brotizolam may be related to its high efficacy at the benzodiazepine/GABA-gated chloride channel.
Brotizolam enhanced GABA (30 microM)-stimulated 36Cl- influx (146.1% of control), while ciclotizolam and WE 1008 showed only a small enhancement (119.3% and 119.1%, respectively) of GABA-stimulated 36Cl- uptake.
Brotizolam resulted in a left shift of the GABA dose response curve at lower concentrations of GABA (10 microM), while at higher concentrations of GABA (1 mM), brotizolam caused a reduction of the maximal response.
These results suggest that 1) brotizolam produces an enhancement of GABA (30 microM)-stimulated chloride influx through the benzodiazepine receptor.
Life sciences  •  1989  |  View Paper
According to the maximum binding of [3H]-flunitrazepam, the inhibition curve of brotizolam also increased in the presence of 10(-4) mol/l gamma-aminobutyric acid and decreased remarkably in the presence of 10(-4) mol/l bicuculline.
Arzneimittel-Forschung  •  1986  |  View Paper