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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and Antipsychotic Agents

Research Papers that Mention the Interaction

The reduction of GABA + Glu)/Cr ratio after neuroleptic treatment may implicate the recovery of normal neuronal function in neurotransmitters.
Investigative radiology  •  1996  |  View Paper
Dyskinetic animals chronically treated with neuroleptics had significant decreases in glutamic acid decarboxylase and GABA in the substantia nigra, the medial globus pallidus, and the subthalamic nucleus, whereas animals without dyskinesias which had been treated similarly had a normal distribution of these biochemical parameters.
Psychopharmacology. Supplementum  •  1985  |  View Paper
Among the right handed schizophrenia patients, the GABA concentration in the ltBG was significantly higher in patients taking typical antipsychotics (1.25+/-0.24 mmol/l) than in those taking atypical antipsychotics (1.03+/-0.24 mmol/l, p=0.026).
Antipsychotic medication may cause changes in GABA concentration, and atypical and typical antipsychotics may have differing effects.
In the ACC, the GABA concentration was negatively correlated with the dose of the antipsychotics (rs=-0.347, p=0.035).
Schizophrenia Research  •  2010  |  View Paper
In psychotic patients there were significant decreases in GABA concentrations in the amygdala and nucleus accumbens.
Journal of the Neurological Sciences  •  1980  |  View Paper
There was a significant decline of 12 per cent in mean GABA levels in the CSF after a mean of two months of neuroleptic treatment.
The British journal of psychiatry : the journal of mental science  •  1978  |  View Paper
This decrease in released pallidal GABA may play a role in the low motor side‐effect liability of atypical APDs.
Journal of neurochemistry  •  2002  |  View Paper
Neuroleptics including haloperidol and quetiapine enhanced the desensitization of the GABA (3 μM)‐current.
British journal of pharmacology  •  2002  |  View Paper
Changes in striatopallidal GABA are believed to play a significant role in the motor side effects produced by antipsychotic drugs (APDs).
Neuroreport  •  2001  |  View Paper
These latter antipsychotics have antagonistic actions at several receptors, including alpha-1 and alpha-2 adrenergic, M1 muscarinic and gamma-aminobutyric acid (GABA)-A receptors.
The Journal of pharmacology and experimental therapeutics  •  1997  |  View Paper
Results indicate a correlation between increased gamma-aminobutyric acid levels in the GP and the propensity of the APDs tested to induce motor side effects.
The Journal of pharmacology and experimental therapeutics  •  1996  |  View Paper
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