Possible Interaction: Gamma-Aminobutyric Acid and Antipsychotic Agents

“The reduction of GABA + Glu)/Cr ratio after neuroleptic treatment may implicate the recovery of normal neuronal function in neurotransmitters.”

“Dyskinetic animals chronically treated with neuroleptics had significant decreases in glutamic acid decarboxylase and GABA in the substantia nigra, the medial globus pallidus, and the subthalamic nucleus, whereas animals without dyskinesias which had been treated similarly had a normal distribution of these biochemical parameters.”

“Among the right handed schizophrenia patients, the GABA concentration in the ltBG was significantly higher in patients taking typical antipsychotics (1.25+/-0.24 mmol/l) than in those taking atypical antipsychotics (1.03+/-0.24 mmol/l, p=0.026).”

“ Antipsychotic medication may cause changes in GABA concentration, and atypical and typical antipsychotics may have differing effects.”

“In the ACC, the GABA concentration was negatively correlated with the dose of the antipsychotics (rs=-0.347, p=0.035).”

“In psychotic patients there were significant decreases in GABA concentrations in the amygdala and nucleus accumbens.”

“There was a significant decline of 12 per cent in mean GABA levels in the CSF after a mean of two months of neuroleptic treatment.”

“This decrease in released pallidal GABA may play a role in the low motor side‐effect liability of atypical APDs.”

“ Neuroleptics including haloperidol and quetiapine enhanced the desensitization of the GABA (3 μM)‐current.”

“Changes in striatopallidal GABA are believed to play a significant role in the motor side effects produced by antipsychotic drugs (APDs).”

“These latter antipsychotics have antagonistic actions at several receptors, including alpha-1 and alpha-2 adrenergic, M1 muscarinic and gamma-aminobutyric acid (GABA)-A receptors.”

“Results indicate a correlation between increased gamma-aminobutyric acid levels in the GP and the propensity of the APDs tested to induce motor side effects.”