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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“Enhancement of chloride ion conductance through the -aminobutyric acid type A or glycine receptor occurs in the presence of a number of inhaled anesthetics , and the resulting hyperpolarization of the plasma membrane is consistent with decreased neuronal activity.”
Noninactivating tandem pore domain potassium channels as attractive targets for general anesthetics.“More recent studies, however, have revealed that the receptors for inhibitory neurotransmitters such as γ-aminobutyric acid (GABA) and glycine are sensitive to clinically relevant concentrations of inhaled anaesthetics.”
“ Inhaled anesthetics such as isoflurane act to enhance responses to submaximal concentrations of GABA , but it is not clear whether their effect is mediated by an increase in the binding of the agonist or by changes in receptor gating behavior.”
“Because inhaled anesthetics robustly enhance GABA A receptor (GABAA-R) responses to GABA , these receptors are considered prime targets of anesthetic action.”
α1 Subunit-Containing GABA Type A Receptors in Forebrain Contribute to the Effect of Inhaled Anesthetics on Conditioned Fear
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