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Discover Supplement-Drug Interactions

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Last Updated: 5 months ago

Possible Interaction: Gamma-Aminobutyric Acid and Anesthetics, General

Research Papers that Mention the Interaction

Many anxiolytics, anticonvulsants and general anesthetics modulate gamma-aminobutyric acid type A (GABAA) receptors.
The general anesthetics both potentiate GABA and activate GABAA receptors directly, but their binding sites on the receptor are poorly defined.
The Journal of pharmacology and experimental therapeutics  •  1995  |  View Paper
The fast inhibitory actions of GABA are mediated by GABA type A receptors (GABA(A)Rs); they mediate both phasic and tonic inhibition in the brain and are the principle sites of action for anticonvulsant, anxiolytic, and sedative-hypnotic agents that include benzodiazepines, barbiturates, neurosteroids, and some general anesthetics.
Physiological reviews  •  2011  |  View Paper
Benzodiazepines (BZDs), barbiturates, ethanol, and general anesthetics potentiate the action of gamma-aminobutyric acid (GABA) at the type A GABA receptor (GABA(A)R) and have profound effects on mood, arousal, and susceptibility to seizures.
Journal of neurochemistry  •  2000  |  View Paper