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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Gamma-Aminobutyric Acid
supplement:
4-Hydroxybutyric Acid
Research Papers that Mention the Interaction
“ GABA increases cerebral circulation by 25.3%, gamma-hydroxybutyric acid by 35.9% and sucinic acid by 20.4%.”
[Role of GABA and its derivatives in regulating cerebral circulation].“ GABA and GABA-related drugs such as muscimol, gamma-hydroxybutyric acid and baclofen injected unilaterally into the substantia nigra of rats elicited contraversive turning.”
“It is suggested that the anxiogenic effects of GHB could be related to its ability to modulate GABA and/or dopaminergic receptors.”
Anxiogenic-like effects of gamma-hydroxybutyric acid (GHB) in mice tested in the light-dark box.“Respiratory frequency (… reduced after GABA (1 mg) but increased after baclofen (0.5 μg), while muscimol (….5 μg) or GHBA (1 mg) did not affect f. However, GHBA administered repeatedly caused a dose-dependent increase in f.Tidal volume (…) decreased in a dose-dependent fashion after i.c.v.”
“Systemic treatment with GHBA and GABA also suppressed motor activity and GHBA caused a subsequent hyperactivity.”
“Different effects of moderate to high doses of gamma-hydroxybutyric acid , including sedation/hypnosis, have been found to be blocked by gamma-aminobutyric acidB (GABAB) receptor antagonists.”
“However, GHB reduced the amplitude of GABAA-IPSPs elicited in pyramidal neurons by paired pulse stimulation and enhanced paired pulse facilitation with respect to control condition, suggesting that GHB reduces GABA release from nerve terminals.”
“These data suggest that GHB induces a selective decrease in the basal and depolarization-induced release of GABA in cerebral cortex, and further, that this action of GHB may play a role in the mechanism by which GHB induces absence seizures.”
“After coapplication of GABA and GHB , a dose-dependent potentiation of the GABA-elicited current by GHB was observed.”
“Preapplication of GHB , prior to the GABA pulses, resulted in a reduction of the current amplitude elicited by GABA.”
“The maximal effect was obtained with 0.5-1 mM GHB , with which the amplitude was enhanced by about 50% with 0.4 or 1 mM GABA.”
“ GHB has been hypothesized to induce this effect via the postsynaptic gamma-aminobutyric acidB (GABAB) receptor.”
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