supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
Possible Interaction: Gamma-Aminobutyric Acid and 2-Phenyl-2-(Dimethylaminoethoxy)-1,7,7-Trimethylbicyclo(2.2.1)Heptane Hemifumarate
Research Papers that Mention the Interaction
“ Deramciclane non-competitively inhibited … uptake of [3H]GABA with a Ki value of 13.7 +/- 0.5 microM and partially displaced specifically bound [3H](R,S)-N-[4,4-…(3-methyl-2-thienyl)-3-butenyl]nipecotic acid ([3H]NNC-328) with high affinity (IC50 = 2.0 +/- 0.7 nM).”
“These results suggest a role for presynaptic inhibition of excitatory amino acid release and GABA uptake in the anxiolytic properties of deramciclane.”
Inhibition of [3H]D-aspartate release by deramciclane.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback