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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and 2-Phenyl-2-(Dimethylaminoethoxy)-1,7,7-Trimethylbicyclo(2.2.1)Heptane Hemifumarate

Research Papers that Mention the Interaction

Deramciclane non-competitively inhibited … uptake of [3H]GABA with a Ki value of 13.7 +/- 0.5 microM and partially displaced specifically bound [3H](R,S)-N-[4,4-…(3-methyl-2-thienyl)-3-butenyl]nipecotic acid ([3H]NNC-328) with high affinity (IC50 = 2.0 +/- 0.7 nM).
These results suggest a role for presynaptic inhibition of excitatory amino acid release and GABA uptake in the anxiolytic properties of deramciclane.
European journal of pharmacology  •  1999  |  View Paper