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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Gamma-Aminobutyric Acid and 1,3-Dpcpx

Research Papers that Mention the Interaction

After reinstatement, application of the A1 adenosine antagonist 1,3-dipropyl-8-cyclopentylxanthine increased GABA tone to inhibit the CRF-R2 action.
The Journal of Neuroscience  •  2014  |  View Paper
DPCPX (0.3, 0.15 microgram, icv) significantly decrease GABA and increase Glu/GABA in brain of mice.
Yao xue xue bao = Acta pharmaceutica Sinica  •  2003  |  View Paper
Coupling efficacy of micro-receptors to presynaptic inhibition of GABA release was increased in dependent mice in the presence of DPCPX.
Neuropharmacology  •  2003  |  View Paper
DPCPX per se enhanced GABA release, indicating inhibition of the release by endogenous adenosine.
Neuroscience  •  2002  |  View Paper
The selective A1 antagonist DPCPX (10–100 nM) increased GABA release, suggesting that endogenous adenosine tonically inhibits GABA release.
Synapse  •  1999  |  View Paper