Possible Interaction: Gallopamil and Calcium Supplement

“Nifedipine and methoxyverapamil (L–type Ca²⁺ channel blockers) blocked high–glucose–induced stimulation of Ca ²⁺ uptake.”

“Sixty percent of calcium entry was inhibited by methoxy‐verapamil , suggesting that activation of voltage dependent calcium channels (VDCC) may be involved in the process.”

“ Methoxyverapamil (D600) reduces the calcium released in response to an action potential.”

“Culture of 10.4-day rat embryos for 60 min in papaverine at 2.4 X 10(-4) M or gallopamil (D-600) at 5.0 X 10(-4) M, agents which reduce the entry of calcium into cells, causes opening of the elevated cephalic neural folds.”

“These results support the hypothesis that nifedipine, gallopamil , diltiazem and cinnarizine inhibit Ca2+‐ and KCl‐induced tension development of rat uterus by reduction of Ca2+ influx.”

“The solubilized binding sites were destroyed by trypsin … by a 10-min incubation at 50 degrees C. Calcium stimulated nimodipine binding slightly at 0.3 mM and inhibited (-)desmethoxyverapamil binding completely with an IC50 of 1.2 mM. Nimodipine binding was reduced by 20% in the presence of EGTA.”

“ Methoxyverapamil inhibited the angiotensin-mediated increase in calcium uptake without affecting the basal rate of calcium uptake.”

“The muscarinic cholinoceptor agonist carbachol and the L-type Ca2+ channel blockers nisoldipine, diltiazem and gallopamil induced negative chronotropic effects.”

“Redistribution is inhibited in the presence of 20 microM free calcium by the calmodulin antagonists trifluoperazine, W-7 and calmidazolium, the calcium channel blockers diltiazem, methoxyverapamil (D-600) and barium chloride, and the local anesthetics, lidocaine and procaine.”

“The capacity of gallopamil to inhibit ionophore-mediated calcium translocation in a two-phase bulk system was inversely related to the pH of the aqueous phase.”