Possible Interaction: Galactose and Xylose

“In tests using adults, arabinose, galactose , inositol, lactose, maltose, mannitol, mannose, melibiose, ribose, sorbitol, trehalose, and xylose significantly reduced mean day survival.”

“Interference for entry into the cells between the following saccharides was found: d-galactose inhibited alpha-methyl d-glucoside transport; d-xylose entry was inhibited by d-glucose; d-galactose transport was inhibited by d-xylose ; a mutual interference between d-galactose and its 2-deoxy analogue was found.”

“The maximum D-xylose transport rate was 3.8 nmol min-1 mg-1 dry cell weight (DCW) with Km value of 6.8 mM. D-xylose uptake was suppressed in the presence of D-glucose, D-galactose and D-fructose but not L-arabinose and D-ribose.”

“D-… of D-xylose … D-galactose via transcriptional activation of the D-xylose-inducible reductase gene, xyrA. XyrA catalyses the first step of the D-galactose oxido-reductive … be an inducer of the downstream genes such as LadB. The deletion of xyrA results in reduced growth on D-galactose.”

“Deletion of ladB in A. niger results in growth arrest on galactitol and significantly slower growth on D-galactose supplemented with a small amount of D-xylose.”

“The additional copy of the PGM2 gene also resulted in a shorter fermentation time during the co-consumption of galactose and xylose.”

“Pulse addition of galactose , which is also transported by a specific transporter, inhibited xylose conversion by 51%, in accordance with noncompetitive inhibition between the galactose and glucose/ xylose transport systems.”

“There is no measurable growth of the wild type Ophiostoma when galactose is the sole carhon source, d-xylose has a stimulating effect on the utilization of galactose in this fungus.”