Possible Interaction: Galactose and Tryptophan

“Tyrosine, tryptophan and histidine amino acids were found to participate in binding of the galactose ligand.”

“As a result, IAA level in the culture supernatant of hepatocytes treated with D-galactosamine and loaded with TRP significantly increased in a time-dependent manner.”

“ Tryptophan protects to some extent the influence of low doses of D-galactosamine on the hydrocortisone induction of tyrosine aminotransferase.”

“Glucose and galactose also inhibited the tryptophan effect whereas a nonabsorbed hexitor, mannitol, was without effect.”

“ Galactose is shown to enhance the intrinsic tryptophan fluorescence of GalR, the source of which is not explained by a change in decay times, but is due to an increase in the pre-exponential factor of the longest of the three fluorescence decay times.”