Possible Interaction: Galactose and Sorbinil

“Further, we determined whether the aldose reductase (AR) inhibitor, Sorbinil , or estrogen (17beta-E2, and its isomer, 17alpha-E2, which exhibits marginal binding affinity for estrogen receptor), administered prior to and concomitant with Gal exposure might prevent or delay mitochondrial membrane depolarization.”

“The coadministration of the aldose reductase inhibitor, sorbinil , with 40 mM galactose completely prevented the inhibitory effect of galactose on [3H]-taurine uptake.”

“Prevention and reversal of galactose cataract in rats with topical sorbinil.”

“Treatment with sorbinil in combination with galactose led to inhibition of cataracts with indication of appearance of vacuoles at longer periods of exposure to the drug.”

“Coadministration of sorbinil partially prevented the effect of galactose feeding on medullary aldose reductase mRNA (to 43% of control).”

“ Galactose feeding significantly reduced cortical aldose reductase mRNA by 29% relative to control (p<0.01), and this was completely reversed by addition of sorbinil.”

“… weight galactose for 15–21 months developed significant thickening of the endothelial basement membranes of capillaries from the frontal cortex of the cerebrum, by comparison … diet (p<0.001), or animals receiving a diet containing 30% galactose together with 250 mg/kg diet of the aldose reductase inhibitor, Sorbinil (…).”

“Administration of the aldose reductase inhibitor, Sorbinil , to rats fed 50% galactose resulted in a significant inhibition of cataract and of galactitol accumulation in nerve and blood (by more that 90%) and retina (by 62%), but did not inhibit development of the retinal microvascular lesions.”

“The inhibition of myo-inositol uptake by cells chronically exposed to increased concentrations of glucose or galactose was due to a noncompetitive type of inhibition that was blocked by the addition of sorbinil.”

“Although the coadministration of sorbinil to the galactose medium protected against the attendant decrease in transport activity, the cessation of exposure of BLECs to galactose was sufficient stimulus to normalize myo-inositol uptake.”

“The coadministration of sorbinil to the galactose medium normalized the myo-[3H]inositol uptake.”

“The simultaneous administration of sorbinil during a nine day Gal incubation significantly protected the enzymatic activity, while the activity of PGH synthase further declined to 41% of control under the same conditions in the absence of sorbinil.”