Possible Interaction: Gadolinium and Calcium Supplement

“This increase in intracellular calcium concentration was dependent on the presence of extracellular calcium ion and was inhibited by treatment with gadolinium ion , a stretch-activated calcium channel blocker.”

“ Gadolinium at concentrations as low as 1–5 μM combined with calcium inhibits proliferation of human colonic epithelial cells more effectively than calcium alone.”

“A complex interplay between gadolinium and co-factors (pro-inflammatory status, vascular injury, high dose of erythropoietin, high levels of calcium , phosphorus, etc.)”

“ Urinary calcium post-oral calcium load was significantly higher in GD + Ca than in GD + UA (0.227 vs 0.168 mg/dl glomerular filtrate, p <0.001).”

“Total Gd and Ca content in the larvae showed a time- and concentration-dependent increase in Gd , in parallel with a reduction in Ca.”

“In the presence of trifluoperazine a slightly higher general calcium signal was detected compared to untreated controls, while gadolinium was found to decrease the intracellular calcium concentration.”

“While gravitactic stimulation of caffeine-treated cells resulted in a kinetics of fluorescence intensity changes comparable to control cells the addition of gadolinium inhibited any calcium concentration change.”

“In addition, gadolinium prevented the valinomycin-mediated increase in intracellular calcium level under hypotonic conditions, revealing the involvement of stretch-activated channels in calcium influx.”

“The only excipient that affected the biodistribution was found in the gadodiamide formulation where the addition of 5% calcium (DTPA-BMA) reduced residual Gd to just less than 10 times greater than that found for the macrocyclic chelates with the lowest residual Gd, gadoteridol and gadoterate.”

“ Ca currents through the SA cation channel were reversibly blocked by 10 microM gadolinium , which was applied to outside surface of excised patches.”