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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Gabapentin and Glutamic Acid

supplement:

Glutamic Acid

Research Papers that Mention the Interaction

Gabapentin , baclofen and CGP 44532 all reduced the electrically stimulated release of [3H]glutamic acid (IC50=20 microM, 0.8 microM and 2 microM, respectively).
European journal of pharmacology  •  2004  |  View Paper
Gabapentin and pregabalin decreased GLU release by 11-26% with R-(-)-3-isobutylgaba being less effective than pregabalin.
The inhibitory effect of gabapentin and related compounds on GLU release may reflect a subtle modulation of VSCC function which normalizes pathological changes in neurotransmitter release.
Neuroscience Letters  •  2000  |  View Paper