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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Gabapentin
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ Gabapentin is a structural analog of gamma aminobutyric acid that binds to the α2-δ site of voltage-dependent calcium channels and modulates the influx of calcium , with a resulting reduction in excitatory neurotransmitter release.”
Gabapentin for once-daily treatment of post-herpetic neuralgia: a review“Acute administration of gabapentin reduced I Ca and Ca2+ transients compared to control conditions.”
“Acute administration of gabapentin to isolated RGCs that had been pretreated further reduced I Ca.”
“In isolated RGCs, pretreatment with gabapentin (4–18 h) reduced I Ca , and cell surface α 2 δ 1 staining was reduced compared to nonpretreated cells.”
Modulation of voltage-gated Ca2+ channels in rat retinal ganglion cells by gabapentin“Results suggest that gabapentin and pinacidil may activate Ca2+ -activated and ATP-sensitive K+ channels in order to produce part of its spinal antiallodynic effect in the Chung model.”
“Furthermore, gabapentin almost completely blocked Ca2+ action potentials and Ca2+ responses elicited by suprathreshold current injection.”
“In addition, gabapentin reduced calcium current sensitivity to dihydropyridine agonist and antagonists.”
“In isolated pancreatic acinar cells, however, gabapentin induced mobilization of intracellular calcium and caused a slight increase in (3)H-thymidine incorporation.”
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