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“ ACTH has been shown to affect GABAergic , dopaminergic, and serotinergic receptor density in chronically treated animals and to alter neuronal membrane lipid fluidity, permeability, and signal transduction.”
“ GABAergic neurons in the bed nucleus of the stria terminalis, preoptic area, and hypothalamus can directly inhibit PVN outflow and thereby reduce ACTH secretion.”
Annals of the New York Academy of Sciences • 2004 | View Paper
“Results are discussed in the light of the possibility that inhibition by the GABAergic system and stimulation by the serotoninergic system might be components of the mechanism controlling the circadian rhythm of ACTH.”