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Last Updated: 3 months ago

Possible Interaction: Fusidic Acid and Berberine Hydrochloride

Research Papers that Mention the Interaction

In addition, phase contrast micrographs confirmed that biofilm formation was significantly inhibited and mature biofilm was obviously destructed when FA was used in combination with BBR.
It was found in the present study … combined use of fusidic acid FA ) and berberine chloride (BBR) offered an in vitro synergistic action against 7 of the 30 clinical methicillin-resistant Staphylococcus aureus (MRSA) strains, with a fractional inhibitory concentration (FIC) index ranging from 0.5 to 0.19.
The time-kill curve experiment showed that FA plus BBR yielded a 4.2 log10 c.f.u./ml reduction in the number of MRSA 4806 bacteria after 24-h incubation as compared with BBR alone.
These results provide evidence that combined use of FA and BBR may prove to be a promising clinical therapeutic strategy against MRSA.
Viable count analysis showed that FA plus BBR produced a 3.0 log10 c.f.u./ml decrease in biofilm formation and a 1.5 log10 c.f.u./ml decrease in mature biofilm in viable cell density as compared with BBR alone.
World journal of microbiology & biotechnology  •  2014  |  View Paper