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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Furosemide
supplement:
Vitamin C
Research Papers that Mention the Interaction
“This study evaluated whether vitamin C has beneficial effects on renal function or augments the renal effects of furosemide in patients with heart failure.”
Reduction of oxidative stress augments natriuretic effect of furosemide in moderate heart failure.“The following possible explanations for the significant increases in the oral bioavailability and … furosemide observed when ascorbic acid was coadministered to dogs were investigated: ascorbic acid … furosemide , might inhibit GI wall metabolism of furosemide, might enhance the reabsorption … might increase the unionized fraction of furosemide at the receptor sites.”
“The significant increases in the diuretic and natriuretic effects of furosemide with ascorbic acid could be the result of increases in the reabsorption of furosemide from renal tubules and increases in the unionized fraction of furosemide at the renal tubular receptor sites.”
Mechanism of ascorbic acid enhancement of the bioavailability and diuretic effect of furosemide.
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