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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Furosemide
supplement:
Tubocurarine
Research Papers that Mention the Interaction
“ Furosemide (10-6-10-4 M) reduced the concentration of d-tubocurarine required to achieve 50% twitch tension depression in the indirectly stimulated rat diaphragm.”
“In contrast, in higher doses (1–4 mg/kg) furosemide produced stimulusbound repetitive neural activity, initiated neural activity, increased the force of muscle contraction, enhanced nerve and muscle responses to NaF and dibutyrl cyclic AMP, and antagonized d-tubocurarine and succinylcholine blockades.”
Effects of Furosemide on the Neuromuscular Junction“A tendency toward an antagonism between d-tubocurarine and furosemide was observed on skeletal muscle relaxation both in vivo and in situ.”
“Preliminary spectrophotometric evidence suggests that a complex between furosemide and d-tubocurarine exists, which may possibly explain an antagonism between the two drugs.”
“The effect of d-tubocurarine on blood pressure was also antagonized by treatment of the animal with furosemide.”
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