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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Furosemide
supplement:
Thiamine
Research Papers that Mention the Interaction
“There is also evidence that furosemide may directly inhibit thiamine uptake at the cellular level.”
Does Long-Term Furosemide Therapy Cause Thiamine Deficiency in Patients with Heart Failure? A Focused Review.“A two-sample t test estimated the association between frusemide use and thiamin concentration and regression between thiamin concentration and EGFR.”
“Treatment with 50 mg/day thiamine intravenously and 80 mg/day furosemide resulted in increase in urine output, decrease in cardiac output, resolution of pulmonary effusion, and about 70 kg body weight loss.”
“Our results demonstrate that furosemide and digoxin inhibit thiamine uptake by cardiac cells in culture and may therefore cause thiamine deficiency in patients undergoing chronic treatment with these drugs.”
“The effect of furosemide or digoxin on thiamine uptake was found to be dose dependent.”
“ Thiamine uptake by cardiac cells grown in a thiamine-free medium for 7 days decreased significantly in the presence of furosemide or digoxin.”
Furosemide and digoxin inhibit thiamine uptake in cardiac cells.“In the absence of ATP, the Na(+)‐K(+)‐ATPase inhibitors ouabain, frusemide and vanadate reduced thiamine uptake by 35, 30 and 15% respectively.”
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