Possible Interaction: Furosemide and Methionine

“A and B combined with a diuretic furosemide , F) and M decreased the arterial pressures and heart rates equally well by both clinical and AAP measurements (p less than .001).”

“Loop perfusion of either ROMK inhibitor or furosemide caused dose-dependent blunting of TGF, but the response to furosemide was 10-fold more sensitive (IC50 = 10-6 M for furosemide and IC50 = 10-5 M for compound C).”

“… 10−5 M furosemide in the lumen caused a decrease inKe from 4.31±0.43 to 3.17±0.25 (P<0.01) in association with … TALH is mainly an active process requiring aerobic metabolism; (b) dissociation of Ca2+ and Cl− transport may occur under some experimental conditions.”

“Further, furosemide inhibited oxygen consumption by a maximum of 50% at 10−3 M and also had no inhibitory effect if either sodium or chloride were absent.”

“When a bolus of 3 × 10−2 M furosemide was applied intra‐arterially the endolymphatic potential declined at the exceedingly rapid rate of about 10 mv/sec, strongly suggesting that the action of the drug takes place in the vicinity of the capillaries of the stria vascularis.”

“ Furosemide caused a transient increase in the M leads to S flux of Na and Cl but ADH was without effect.”