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European journal of pharmacology • 1998 | View Paper
“ Furosemide at a concentration of 1 mM depressed the maximal peak amplitude of the dose-response curve for either GABA or glycine to about 70% of control.”
“ Furosemide inhibited the peak amplitude of either GABA or glycine current in a dose-dependent manner; its half-maximal concentration for them was some 2 and 1 mM, respectively.”
“These results indicate that furosemide inhibits in a noncompetitive fashion GABA and glycine receptor-channels in septal neurons.”
“ Furosemide (0.1-0.5 mM) changed equilibrium potentials of inhibitory postsynaptic currents, gamma-aminobutyric acid-A (GABAA) or glycine receptor-mediated Cl- currents by a blockade of Cl(-)-outward transport.”