Possible Interaction: Furosemide and Calcium Supplement

“From 0 to 4 h, both torasemide and furosemide significantly increased the urinary flow rate and the urinary excretion of sodium, chloride and calcium , while they decreased the urinary osmolality when compared to placebo.”

“Administration of furosemide significantly enhanced the urinary excretion of Na and Cl at 0 to 24, 24 to 48 and 48 to 72 hours and of Ca at 24 to 48 and 48 to 72 hours after drug administration.”

“Urine output and urine sodium and calcium loss were significantly increased (P less than .05) in the infants receiving furosemide.”

“These drugs … range) some CA isozymes involved in critical physiologic processes, among the 16 present in vertebrates, for example, metolazone against CA …, chlorthalidone against CA VB, VII, IX, XII, and XIII, indapamide against CA VII, IX, XII, and XIII, furosemide against CA I, II, and … CA IX and XII.”

“The effect of magnesium loading on calciuria was still observed after treatment with furosemide , which disrupts calcium and magnesium absorption in the thick ascending limb, suggesting that the effect may be mediated by the distal nephron.”

“Other commonly used medications to further decrease calcium include bisphosphates, calcitonin, steroids, and (rarely) furosemide.”

“Age (r=0.256, p<0.001), serum creatinine (r=0.139, p=0.030), mean of right arm systolic BP (SBP; … of left arm SBP (r=0.190, p=0.002), inter-arm SBP difference (r=0.152, p=0.014), and the FRS (r=0.… with CACS.”

“The CAC scores rose significantly as the FRS grew more severe (P < 0.01).”

“In conclusion, CAC screening could be of benefit in refining risk assessment of low-risk men, but only when the FRS exceeds approximately 5%.”

“They described that furosemide is known to enhance the excretion of calcium into the urine; however, a similar action with bile has not been investigated [2, 3].”