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Last Updated: 5 months ago

Possible Interaction: Fosfomycin and Glycopeptides

supplement:

Glycopeptides

Research Papers that Mention the Interaction

If these results are confirmed by in vivo experiments, the combination of fosfomycin with glycopeptides might be useful for treating device-associated infections, and in preventing the phenomenon of increasing MICs for glycopeptides.
Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive  •  2005  |  View Paper
In conclusion, the concomitant administration of FOM and glycopeptide antibiotics may help to achieve a chemotherapeutic stra-tegy that reduces the nephrotoxic effects of glycopeptide antibiotics.
In the present study, FOM decreased glycopeptide antibiotic-induced nephrotoxicity as shown by reduced urinary excretion of N-acetyl-β-D-glucosaminidase (NAG) as well as fewer histopathological signs of nephrotoxicity in the groups treated with the combination of glycopeptide and FOM as compared with a glycopeptide alone.
The accumulation of teicoplanin and vancomycin was significantly lower in the renal cortex of rats treated with the combination of glycopeptide antibiotics and FOM as compared with glycopeptide antibiotics alone (P < 0.05).
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy  •  2001  |  View Paper