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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Formononetin and Temozolomide

supplement:

Formononetin

Research Papers that Mention the Interaction

Conclusions This study has identified that calycosin and FMN can increase the treatment effect of TMZ in vitro and in vivo.
Results The efficacy of TMZ on glioma could be enhanced by combining with calycosin and FMN through inhibiting the proliferation and migration of glioma cells and promoting their apoptosis.
Journal of ethnopharmacology  •  2019  |  View Paper
In conclusion, formononetin in combination with TMZ can play a synergistic role in anti-C6 cells, the mechanisms of synergy depended on multiple pathways.
These results showed that formononetin or TMZ alone could inhibit the growth of C6 cells in dose-dependent manner and formononetin in combination with TMZ had synergy effect on C6 cells.
Biological & pharmaceutical bulletin  •  2018  |  View Paper
Co-treatment with other chemotherapy drugs such as bortezomib, LY2940002, U0126, sunitinib, epirubicin, doxorubicin, temozolomide , and metformin enhances the anticancer potential of both formononetin and the respective drugs through synergistic effect.
Front. Pharmacol.  •  2019  |  View Paper