Possible Interaction: Folic Acid and Vitamin E

“However, chronic treatment comprising folic acid plus α-tocopherol was ineffective on Aβ-induced glial cell activation, suggesting that the effect of this treatment is independent of anti-inflammatory features.”

“Of note, the chronic treatment comprising folic acid plus α-tocopherol prevented …₋₄₀. Together, these results show the antioxidant effect of the combination of folic acid … α-tocopherol , as observed by the decrease in NO generation from iNOS and …, and the neuronal death induced by the Aβ₁₋₄₀ peptide.”

“IL-6 and TNF-α expressions were significantly lower in combined Ve with Ω-3 FA than treatment with Ve or Ω-3 FA alone.”

“Especially vitamin E in combination with other vitamins like vitamin C, vitamin B1, B2, B6, B12, niacin, folic acid , pantothenic acid and selenium, was significantly associated with lower CRP levels.”

“The combination of vitamin B9 and vitamin E deprivation could be deleterious for endothelial function, since these antioxidants have been implicated in the modulation of nitric oxide and eicosanoid signalling.”

“The increase in plasma vitamin E levels after the administration of vitamin E at a … 100 mg three times daily for 4 weeks was higher than that obtained when vitamin E at the same … administered together with vitamin B-complex for 4 weeks, suggesting an … between the two vitamins.”

“Similarly, ApoE knockout mice exhibited no significant differences following dietary iron challenge in the presence or absence of vitamin E. However, … knockout mice accumulated significantly increased TBARs following iron challenge when folic acid was withheld, and accumulated even more TBARs when both folic acid and vitamin E were withheld.”