Possible Interaction: Folic Acid and Vitamin C

“The addition of 100 mg % vitamin C decreased mean worm numbers and worm length in chicks deficient in both vitamin B 12 and PGA , but had no effect in the presence of vitamin B 12 .”

“In 1944, Briggs et al. (5) observed a growth stimulation in chicks when vitamin C was added to a purified diet containing crude concentrates of folic acid.”

“Addition of vitamin-mineral complex to patients ration course 30 days resulted in eliminating insufficiently of vitamin C , carotinoids, beta-carotin, calcium and in hardly noticable changes of initial high levels of vitamin A, E, B and phosphoris.”

“… vitamin C (OR = 0.2, for the highest versus the lowest intake quintile; 95% CI: 0.…–0.6), β-criptoxanthin (OR = 0.4; 95% CI: 0.2–0.5), folic acid (OR = 0.4; 95% CI: 0.2–0.6), … (OR = 0.6; 95% CI: 0.4–0.9).”

“Therapy with ascorbic acid resulted in reduction of the urinary excretion of folic acid-like activity, with no significant changes in the excretion of citrovorum factor.”

“The recovery of citrovorum factor present in the urine of male rats receiving folic acid is enhanced both by in vitro addition of ascorbic acid to the collection bottles and by in vivo stomach tube feeding of ascorbic acid.”

“Both cyanocobalamin and folic acid probably participate in synthesis of nucleoprotein, and ascorbic acid may function as a hydrogen donor in the conversion of folic acid to tetrahydrofolic and folinic acids.”

“A potentiation of this hematologic effect of PGA occurred on subsequent administration of 1 g of ascorbic acid daily in addition to the PGA.”

“We have explored the relation of ascorbic acid deficiency ….3All the evidence indicates that the requirement for folic acid … ascorbic acid , especially when so severe as to lead to scurvy.4This mechanism may be of … a series of infections, even though the intake of ascorbic acid was unquestionably adequate.”

“The administration of sulfasuxidine to a semi-purified ration eliminates the increase of the PGA liver storage produced by vitamin C. Both vitamin C and vitamin B12 raise the caecal concentration of PGA in the chick.”