Possible Interaction: Folic Acid and Vitamin B Complex

“This phenomenon termed eNOS uncoupling switches the enzyme from a … antioxidants such as vitamin B, C, and E and with folic acid … B vitamins are in general disappointing, and in some aspects, vitamins are accused even to … The Ongoing Outcome (TOO)6 trials revealed that vitamin E more often …”

“Although folic acid and vitamin B supplementation are thought … study was performed to investigate whether a supplement combining folic acid … vitamin B could reduce the risk of major cardiovascular events in 5,552 patients with vascular … control group, even though the homocysteine level in the active control group decreased.”

“Furthermore, these findings raise questions about whether the combination of folic acid and B vitamins may actually be harmful.”

“The folic acid plus vitamin B 12 supplementation significantly changed the Full Scale IQ (effect size d = 0.169; P = 0.024), verbal IQ (effect size d = 0.146; P = 0.033), Information (d = 0.172; P = 0.019) and Digit Span (d = 0.187; P = 0.009) scores.”

“4) After treatment with vitamin B and folic acid , the CysC, and HCY levels were lower than before, but the grades of the repetition measurement scale, MMSE and MoCA had no significant improvement (p>0.05).”

“This review advocates a proposal for combined fortification of folic acid and vitamin B (12) to address possible hazards of fortification with folic acid alone.”

“Multiple Vitamin Combinations The incremental benefit of taking supplemental doses of folic acid and B vitamins has been examined by comparing the outcomes of observational studies while controlling for the total intake of antioxidant vitamin supplements (35).”

“One complication of folic acid supplementation that has been cited is delaying the diagnosis of vitamin B , deficiency, resulting in the progression of neuro ‘1 ogic sequelae.”

“Administration of folic acid adversely affected the serum vitamin B 12 level of eighteen of twenty-seven patients receiving 20 or 30 μg of vitamin B 12 intramuscularly every two weeks, possibly by accelerating the utilization of vitamin B 12 .”