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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Folic Acid
supplement:
Vitamin B 6
Research Papers that Mention the Interaction
“Intention-to-treat analyses limited to participants (… showed that compared with placebo, treatment with folic acid … pyridoxine was associated with a 3.7-mm Hg (95% CI −6.8 to −0.6 mm ….7 to −0.02 mm Hg) lower diastolic blood pressure over the 2-year trial period.”
“Together with the decreased occurrence of abnormal exercise electrocardiography tests reported previously, our results support the hypothesis that homocysteine-lowering treatment with folic acid plus pyridoxine has beneficial vascular effects.”
Long-Term Homocysteine-Lowering Treatment With Folic Acid Plus Pyridoxine Is Associated With Decreased Blood Pressure but Not With Improved Brachial Artery Endothelium-Dependent Vasodilation or Carotid Artery Stiffness: A 2-Year, Randomized, Placebo-Controlled Trial“Additionally, the reduction in these characteristics of migraine attacks in the folic acid plus pyridoxine group was significant compared with the group given folic acid alone (P < 0.001).”
“The treatment group did not show a significant decrease in the … of the 6 month intervention (P > 0.1).Conclusion1 mg of folic acid … vitamin B6 and B12 is less effective in reducing migraine associated symptoms compared to … 25 mg of vitamin B6 and 400 μg of vitamin B12.”
“The risk of stroke was lower with folic acid plus vitamin B6 as compared with folic acid plus vitamin B12 and was lower with folic acid plus vitamin B6 plus vitamin B12 as compared with placebo or folic acid plus vitamin B12.”
“BACKGROUND & AIMS There is a growing amount of data and a continuing controversy over the effect of folic acid supplementation with and without vitamin B6 on revascularization risk.”
“In the total … Z 68), vitamin B6 significantly correlated with forced expiratory volume in 1 s, % predicted, (FEV1%) (r Z 0.24, p Z 0.04), FEV1/… 0.30, p Z 0.01), C-reactive protein (CRP) (r Z 0.25, p Z 0.04) and with folic acid (…).”
“The use of folic acid and vitamin B6 was associated with a lower prevalence of atherothrombotic events in 8008 women [5].”
“A second concern is that the very high doses of folic acid and pyridoxine being used in the HOST may confound the results.”
“Thrombotic events related to slightly elevated levels of homocystein in adults may be decreased by daily consumption of 1 mg of folic acid together with 5 - 100 mg of pyridoxine.”
“ Folic acid combined with vitamins B-6 and B-12 significantly lowered tHcy (6.5 +/- 0.5 micromol/L).”
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