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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Folic Acid
drug:
Trimethoprim
Research Papers that Mention the Interaction
“ Trimethoprim has been shown by Kahn et al. [6] and Jenkins et al. [7] to affect hemoglobin, neutrophil and platelet counts, and folic acid levels in vivo.”
Methotrexate-induced pancytopenia associated with co-prescription of penicillin and trimethoprim“It is recommended that folic acid supplementation is provided to the mother when being treated with trimethoprim (7).”
“In two out of four women carrying the Xqfra and in three out of four Xfra mentally retarded boys, treated for a few months, with oral folic acid (one milligram/kg/day), TMP increased the frequency of the gap, while PMT was practically inactive.”
“The results indicated that cellular uptake of 5‐methyltetrahydrofolate, folic acid and methotrexate could be inhibited by trimethoprim ; the inhibition, for methotrexate at least, was competitive, but it was in every case rather weak.”
“SMX and TMP inhibit folic acid biosynthesis and are used in combination to treat infections of the respiratory, urinary, and gastrointestinal tracts.”
The Combination of Sulfamethoxazole, Trimethoprim, and Isoniazid or Rifampin Is Bactericidal and Prevents the Emergence of Drug Resistance in Mycobacterium tuberculosis
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