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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Folic Acid
drug:
Triamterene
Research Papers that Mention the Interaction
“ Folic acid and methotrexate are able to inhibit triamterene absorption.”
Kinetic modeling of triamterene intestinal absorption and its inhibition by folic acid and methotrexate.“In an in vivo intestinal loop method, triamterene inhibited the intestinal absorption of folic acid in a dose-dependent fashion, with 50% inhibition of systemic absorption occurring at a luminal concentration of 0.01 mmol/L of triamterene.”
“Abstract Triamterene has been found to inhibit the activity of folic acid reductase from murine leukemic cells by 50% at approximately 8 × 10−7 M. The inhibition due to triamterene was competitive with folic acid at low inhibitor concentrations.”
“At all concentrations, the inhibition obtained with triamterene was either partially or completely reversed by increasing the folic acid concentration.”
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