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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Folic Acid
drug:
Tetrahydrofolate
Research Papers that Mention the Interaction
“The inhibitory effects of FA and tetrahydrofolate ( THF ), a metabolite of FA produced by DHFR, on MTX-induced increases in mRNA expression of α-SMA, an EMT marker, were compared.”
Investigation on inhibitory effect of folic acid on methotrexate-induced epithelial-mesenchymal transition focusing on dihydrofolate reductase.“Due to folic acid ’s known ability to inhibit DHFR’s recycling of DHF to THF , more DHF remains available to bind to the enzyme methylenetetrahydrofolate reductase (MTHFR) and so inhibits MTHFR in turn (Matthews & Daubner 1982).”
“ Folic acid caused a 10- and a 5-fold increase in 5-MTHF and THF , respectively, and lowered tHcy (median tHcy = 17.2 μmol/L at baseline vs 9.0 μmol/L after treatment).”
“Supplementation with folic acid elicited a significant increase in mucosal 5-methyl tetrahydrofolate , and a marked increase in RBC and plasma, with a dose-response.”
“Binding of [3H]PteGlu at the high-affinity sites was inhibited by tetrahydrofolate and N5-methyltetrahydrofolate, but not by several other structural analogues.”
“C3H mouse mammary adenocarcinomas from mice maintained on a folic acid deplete diet had modestly decreased methylenetetrahydrofolate and tetrahydrofolate levels, and were somewhat less responsive to FU alone compared with replete animals.”
Impact of schedule on leucovorin potentiation of fluorouracil antitumor activity in dietary folic acid deplete mice.
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