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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Folic Acid
drug:
Sulfadoxine
Research Papers that Mention the Interaction
“ Sulfadoxine activity was antagonised slightly by p-aminobenzoic …-aminobenzoylglutamic acid, and antagonised markedly by folic acid at concentrations above 4 X 10(-8) M. At 10(-7) M folic acid, a concentration lower … normal RPMI medium 1640, sulfadoxine activity was reduced 7000 to 9000-fold in comparison with controls.”
Antagonism of sulfadoxine and pyrimethamine antimalarial activity in vitro by p-aminobenzoic acid, p-aminobenzoylglutamic acid and folic acid.“ Folic acid added to this medium at a physiological concentration of 0.01 mg/liter caused a 1,000-fold reduction in sulfadoxine activity; a 100-fold higher concentration of folic acid caused a 10-fold reduction in pyrimethamine activity.”
“The antimalarial activity of sulforthomidine was inhibited by folic acid and p-aminobenzoic acid.”
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